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;In vivo: MK-4827 is nicely tolerated in vivo and demonstrates efficacy as one agent in a xenograft design of BRCA-1 deficient cancer [1]. On top of that, MK-4827 strongly improves the impact of radiation on a range of human tumor xenografts, both of those p53 wild form and p53 mutant. The improvement of radiation reaction is noticed in clinically

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